Mysimba is a prescription weight-loss pill that, when taken alongside a healthy diet and regular exercise, can help manage your weight if you are overweight or obese. It contains 2 active ingredients, naltrexone and bupropion, which suppress your appetite and act on brain reward centers. This can reduce cravings and food noise, supporting you to follow a reduced-calorie diet and lose weight.

It is taken daily, starting with 1 tablet and gradually increasing to a maximum of 4 tablets per day over time.

Research indicates that individuals can lose an average of 8.1% of their initial body weight after 56 weeks. Mysimba is a prescription medication that can only be obtained privately.

Mysimba weight loss tablets contain naltrexone and bupropion, and these work on the specific area of the brain that controls how much food you eat and how energy is spent. By affecting food cravings, it makes it less likely you’ll overeat, which can lead to significant weight loss if you make adjustments to your lifestyle too.

The ingredient bupropion is also used in some antidepressant medications, as well as a popular stop-smoking treatment called Zyban. So Mysimba is quite different from the weight loss tablet Orlistat, which affects how much fat you take up from food.

Mysimba has demonstrated significant effectiveness in clinical trials, especially when used in conjunction with weight loss management counseling. In a study involving participants over 56 weeks, the average weight loss was 5.4%. However, among those who also received behavioral support, the average weight loss increased to 8.1%.

In a combined analysis of studies, up to 42% of people taking Mysimba over 56 weeks lost at least 5% of their body weight, and up to 22% lost 10% of their body weight. So it has proven to be effective for a sizeable portion of people who take it.